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Nat Commun 11:498 Lee YZ, Yang CW, Chang HY et al (2014) Discovery of selective inhibitors of glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

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Quantitative prediction of in vivo drugdrug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver

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However, clinical translation is limited by metabolic sequelae: Ghrelin inhibits pancreatic -cell KATP channels to reduce insulin secretion, potentially exacerbating postprandial glycemiaa critical concern in DGE

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What Makes It Different Built around micronized creatine monohydrate (a highly studied form) that mixes easily and is often easier to digest

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